主要学习工作经历

· 2020至今 上海浦东复旦大学张江科技研究院，研究员

· 2018至今 复旦大学附属华山医院运动医学科，副研究员

· 2013-2013 University of Nottingham，访问学者

· 2010-2013 上海交通大学生物医学工程系，博士

· 2006-2009 福州大学生物化学与分子生物学系，硕士

· 2002-2006 西南科技大学制药工程系，学士

主要研究方向和领域

· 肌骨系统损伤与修复

· 肌骨系统运动机理与模拟

· 人工肌腱与人工韧带

奖励资助和社会服务

获国家教育部科学技术进步奖二等奖、中华医学会医学科学技术二等奖、上海医学科技奖二等奖，上海市青年科技启明星计划，上海市人才发展基金，复旦大学卓越2025计划卓学人才等。

代表性论文和论著

1. Yuzhou Chen#, Mo Chen#, Chengxuan Yu#, Huizhu Li, Liman Sai, Nguyen T. K. Thanh, Yueming Wang, Yan Wo, Jian Zhang, Xing Yang, Evgenii L. Guryev, Andrei V. Zvyagin, Hao De, Min Tang, Shiyi Chen, Yunxia Li*, Yuefeng Hao*, Sijia Feng*, Jun Chen*. In vivo Real-time Monitoring Delayed Administration of M2 Macrophages to Enhance Healing of Tendon by NIR-II Fluorescence Imaging. Nano Research.2023 Dec, In press.

2. Mo Chen#, Yuzhou Chen#, Sijia Feng#, Shixian Dong, Luyi Sun, Huizhu Li，Fuchun Chen, Nguyen Thi Kim Thanh, Yunxia Li, Shiyi Chen, You Wang*, Jun Chen*. SWIR Fluorescence Imaging In Vivo Monitoring and Evaluating Implanted M2Macrophages in Skeletal Muscle Regeneration. Engineering. 2023 June 7:in press

3. Xinxian Meng#, Huizhu Li#, Yuzhou Chen#, Liman Sai, Sijia Feng, Ke Li, Wenjing Xi, Yunxia Li, Nguyen T. K. Thanh, Yueming Wang, Yan Wo, Xing Yang, Yuefeng Hao*, Yixin Zhang*, Jun Chen*, Shaoqing Feng*. In Vivo Precision Evaluation of Lymphatic Function by SWIR Luminescence Imaging with PbS Quantum Dots. Advanced Science. 2023 January 01; 2206579.

4. Sijia Feng#, Mo Chen#, Yuzhou Chen#, Liman, Sai, Shixian Dong, Huizhu Li, Yimeng Yang, Jian Zhang, XingYang, Xiaogang Xu, Yuefeng Hao, AmrMohamed Khair Hussein Abdoug, Ngoc Quyen Tranhi, Shiyi Chen, Yunxia Li*, Jingcheng Dong*, Jun Chen*. Seeking and identifying time window of antibiotic treatment under in vivo guidance of PbS QDs clustered microspheres based NIR-II fluorescence imaging. Chemical Engineering Journal. 2023 Jan 01; 451(1), 13858.

5. Chengxuan Yu^#, Sijia Feng^#, Yunxia Li*, Jun Chen*. Application of Nondegradable Synthetic Materials for Tendon and Ligament Injury. Macromolecular Bioscience. 2023 Jul doi: 10.1002/mabi.202300259.

6. Yuting Zhong^#, Wenhe Jin^#, Han Gao, Luyi Sun, Peng Wang, Jian Zhang,Michael Tim Yun Ong, Fu Sai Chuen Bruma, Shiyi Chen, Jun Chen*. A Knitted PET Patch Enhances the Maturation of Regenerated Tendons in Bridging Reconstruction of Massive Rotator Cuff Tears in a Rabbit Model. The American Journal of Sports Medicine. 2023 Feb 20; 3635465231152186.

7. Jun Chen#, Dandan Sheng#, Ting Ying#, Haojun Zhao, Jian Zhang, Yunxia Li, He Xu*, Shiyi Chen*. MOFs-Based Nitric Oxide Therapy for Tendon Regeneration. Nano-micro letters. 2020 Nov 11;13(1):23.

8. Jun Chen#, Sijia Feng#, Mo Chen#, Pei Li, Yimeng Yang, Jian Zhang, Xiaogang Xu*, Yunxia Li*, Shiyi Chen*. In vivo Dynamic Monitoring of Bacterial Infection by NIR-II Fluorescence Imaging. Small. 2020 Aug;16(34):e2002054.

9. Zhujun Feng#, Yimeng Yang#, Jian Zhang, Kan Wang, Yunxia Li, Heng Xu, Zhen Wang, Ewelina Biskup, Shixian Dong, Xing Yang, Yuefeng Hao, Jun Chen*, and Yan Wo*. In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window. Nano Research. 2019 Oct 24; 12(12):3059-3068.

10. Yimeng Yang#, Jun Chen#*, Xiliang Shang#, Zhujun Feng, Chen Chen, Jingyi Lu, Jiangyu Cai, Yuzhou Chen, Jian Zhang, Yuefeng Hao, Xing Yang, Yunxia Li, Shiyi Chen*. Visualizing the Fate of Intra-Articular Injected Mesenchymal Stem Cells In Vivo in the Second Near-Infrared Window for the Effective Treatment of Supraspinatus Tendon Tears. Advanced Science. 2019 Aug 1;6(19):1901018.

11. Shaoqing Feng, Jun Chen#*, Yan Wo#*, Yunxia Li, Shiyi Chen#*, Yixin Zhang , Wenjie Zhang#*. Real-Time and Long-Time In Vivo Imaging in the Shortwave Infrared Window of Perforator Vessels for More Precise Evaluation of Flap Perfusion”. Biomaterials. 2016 Oct;103:256-264.

12. Yifei Kong, Jun Chen, Hongwei Fang, George Heath, Yan Wo, Weili Wang, Yunxia Li, Yuan Guo, Shiyi Chen* and Dejian Zhou*. Highly Fluorescent Ribonuclease-A-Encapsulated Lead Sulfide Quantum Dots for Ultrasensitive Fluorescence in Vivo Imaging in the Second Near-Infrared Window. Chemistry of Materials. 2016 May 10;28(9):3041-3050.

近五年，以第一/通讯（含共同）作者在Adv. Sci.，Nano-micro Lett，Small，Biomaterials，Mater. Today Adv.等杂志发表SCI30余篇，其中中科院一区14篇。

Prof. Jun Chen

Department of Sport Medicine, Huashan Hospital，Fudan University

Tel&Fax: 021-52888256

Email: biochenjun@fudan.edu.cn, biochenjun@hotmail.com

Education & Work Experience

7/2020-present Distinguished Professor in Zhangjiang Institute of Science and Technology, Fudan University

12/2018-present Associate Professor in Huashan Hospital, Fudan University

9/2010-6/2013 Ph.D. in Biomedicine Engineering, Shanghai Jiao Tong University, China

9/2006-4/2009 M.Sc. in Biochemistry and Molecular Biology, Fuzhou University, China

9/2002-7/2006 Sc. in Pharmaceutical Engineering (Ranked the 1st among the class), Southwest University of Science and Technology, China

Research Interests

I. The diagnosis and regeneration of Musculoskeletal system

II. The Mechanism of Musculoskeletal system in the body and Robot

III. Artificial Ligament and  Artificial Tendon

Publications

1. Yuzhou Chen#, Mo Chen#, Chengxuan Yu#, Huizhu Li, Liman Sai, Nguyen T. K. Thanh, Yueming Wang, Yan Wo, Jian Zhang, Xing Yang, Evgenii L. Guryev, Andrei V. Zvyagin, Hao De, Min Tang, Shiyi Chen, Yunxia Li*, Yuefeng Hao*, Sijia Feng*, Jun Chen*. In vivo Real-time Monitoring Delayed Administration of M2 Macrophages to Enhance Healing of Tendon by NIR-II Fluorescence Imaging. Nano Research.2023 Dec, In press.

2. Mo Chen#, Yuzhou Chen#, Sijia Feng#, Shixian Dong, Luyi Sun, Huizhu Li，Fuchun Chen, Nguyen Thi Kim Thanh, Yunxia Li, Shiyi Chen, You Wang*, Jun Chen*. SWIR Fluorescence Imaging In Vivo Monitoring and Evaluating Implanted M2Macrophages in Skeletal Muscle Regeneration. Engineering. 2023 June 7:in press

3. Xinxian Meng#, Huizhu Li#, Yuzhou Chen#, Liman Sai, Sijia Feng, Ke Li, Wenjing Xi, Yunxia Li, Nguyen T. K. Thanh, Yueming Wang, Yan Wo, Xing Yang, Yuefeng Hao*, Yixin Zhang*, Jun Chen*, Shaoqing Feng*. In Vivo Precision Evaluation of Lymphatic Function by SWIR Luminescence Imaging with PbS Quantum Dots. Advanced Science. 2023 January 01; 2206579.

4. Sijia Feng#, Mo Chen#, Yuzhou Chen#, Liman, Sai, Shixian Dong, Huizhu Li, Yimeng Yang, Jian Zhang, XingYang, Xiaogang Xu, Yuefeng Hao, AmrMohamed Khair Hussein Abdoug, Ngoc Quyen Tranhi, Shiyi Chen, Yunxia Li*, Jingcheng Dong*, Jun Chen*. Seeking and identifying time window of antibiotic treatment under in vivo guidance of PbS QDs clustered microspheres based NIR-II fluorescence imaging. Chemical Engineering Journal. 2023 Jan 01; 451(1), 13858.

5. Chengxuan Yu^#, Sijia Feng^#, Yunxia Li*, Jun Chen*. Application of Nondegradable Synthetic Materials for Tendon and Ligament Injury. Macromolecular Bioscience. 2023 Jul doi: 10.1002/mabi.202300259.

6. Yuting Zhong^#, Wenhe Jin^#, Han Gao, Luyi Sun, Peng Wang, Jian Zhang,Michael Tim Yun Ong, Fu Sai Chuen Bruma, Shiyi Chen, Jun Chen*. A Knitted PET Patch Enhances the Maturation of Regenerated Tendons in Bridging Reconstruction of Massive Rotator Cuff Tears in a Rabbit Model. The American Journal of Sports Medicine. 2023 Feb 20; 3635465231152186.

7. Jun Chen#, Dandan Sheng#, Ting Ying#, Haojun Zhao, Jian Zhang, Yunxia Li, He Xu*, Shiyi Chen*. MOFs-Based Nitric Oxide Therapy for Tendon Regeneration. Nano-micro letters. 2020 Nov 11;13(1):23.

8. Jun Chen#, Sijia Feng#, Mo Chen#, Pei Li, Yimeng Yang, Jian Zhang, Xiaogang Xu*, Yunxia Li*, Shiyi Chen*. In vivo Dynamic Monitoring of Bacterial Infection by NIR-II Fluorescence Imaging. Small. 2020 Aug;16(34):e2002054.

9. Zhujun Feng#, Yimeng Yang#, Jian Zhang, Kan Wang, Yunxia Li, Heng Xu, Zhen Wang, Ewelina Biskup, Shixian Dong, Xing Yang, Yuefeng Hao, Jun Chen*, and Yan Wo*. In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window. Nano Research. 2019 Oct 24; 12(12):3059-3068.

10. Yimeng Yang#, Jun Chen#*, Xiliang Shang#, Zhujun Feng, Chen Chen, Jingyi Lu, Jiangyu Cai, Yuzhou Chen, Jian Zhang, Yuefeng Hao, Xing Yang, Yunxia Li, Shiyi Chen*. Visualizing the Fate of Intra-Articular Injected Mesenchymal Stem Cells In Vivo in the Second Near-Infrared Window for the Effective Treatment of Supraspinatus Tendon Tears. Advanced Science. 2019 Aug 1;6(19):1901018.

11. Shaoqing Feng, Jun Chen#*, Yan Wo#*, Yunxia Li, Shiyi Chen#*, Yixin Zhang , Wenjie Zhang#*. Real-Time and Long-Time In Vivo Imaging in the Shortwave Infrared Window of Perforator Vessels for More Precise Evaluation of Flap Perfusion”. Biomaterials. 2016 Oct;103:256-264.

12. Yifei Kong, Jun Chen, Hongwei Fang, George Heath, Yan Wo, Weili Wang, Yunxia Li, Yuan Guo, Shiyi Chen* and Dejian Zhou*. Highly Fluorescent Ribonuclease-A-Encapsulated Lead Sulfide Quantum Dots for Ultrasensitive Fluorescence in Vivo Imaging in the Second Near-Infrared Window. Chemistry of Materials. 2016 May 10;28(9):3041-3050.

For the last five years, more than 30 SCIs (as the first/corresponding including co-author) were published in journals such as Adv. Sci., Nano-micro Lett, Small, Biomaterials, Mater. Today Adv. etc.